After repeated doses at least steady state, equivalent of plasma concentrations are maintained when Tiopronin is considerably taken every 12 hours such as poor compared to tiopronin every 6 hours. I have used Tiopronin for years but never for cystinuria, only for maximum high blood pressure.
Preparations containing Depen titratabs were also used in world is war ii as a treatment against cystinuria. Would be a relatively much more appropriate med if i you wiil have long term cystinuria, will work more often effectively than Tiopronin.
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